Electrotransport of Donepezil Hydrochloride from Poly(ethylene oxide) Hydrogel

Acrescent, INN- memantine hydrochloride / donepezil hydrochloride

Effect of Donepezil Hydrochloride on Cognitive Function

Objective: To explore the effect of donepezil hydrochloride on the cognitive function recovery of the rats with Alzheimer’s disease and the positive expression of nitric oxide synthase and acetylcholinesterase (NOS and AchE) in brain tissues of rats with Alzheimer's disease (AD). Methods: Forty SD (Sprague Dawley) rats were randomly classified into model group, treatment group, control group an...

Donepezil hydrochloride (E2020) and other acetylcholinesterase inhibitors.

A wide range of evidence shows that acetylcholinesterase (AChE) inhibitors can interfere with the progression of Alzheimer's disease (AD). The successful development of these compounds was based on a well-accepted theory that the decline in cognitive and mental functions associated with AD is related to the loss of cortical cholinergic neurotransmission. The earliest known AChE inhibitors, name...

Bioequivalence Study of Donepezil Hydrochloride Tablets in Healthy Male Volunteers

The objective of this study was to investigate the bioequivalence of two formulations of 5 mg donepezil HCL tablets: Tonizep as the test and Aricept as the reference. The two products were administered as a single oral dose according to a randomized two-phase crossover with a 3-week washout period in 20 healthy Thai Male volunteers. After drug administration, serial blood samples were collected...

Preliminary investigation of a polyethylene glycol hydrogel "nerve glue"

BACKGROUND Polyethylene glycol (PEG) hydrogel is a biocompatible semi-adherent gel like substance that can potentially augment nerve repair much like a fibrin sealant. Potential advantages of this substance include fast preparation and set up time, as well as adhesion inhibiting properties. The purpose of this study was to perform an initial evaluation of PEG hydrogel in this application. MET...